SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset
نویسندگان
چکیده
منابع مشابه
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.
Type 1 diabetes (T1D) results from progressive loss of pancreatic islet mass through autoimmunity targeted at a diverse, yet limited, series of molecules that are expressed in the pancreatic beta cell. Identification of these molecular targets provides insight into the pathogenic process, diagnostic assays, and potential therapeutic agents. Autoantigen candidates were identified from microarray...
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OBJECTIVE Zinc transporter eight (SLC30A8) is a major target of autoimmunity in human type 1A diabetes and is implicated in type 2 diabetes in genome-wide association studies. The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabet...
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ژورنال
عنوان ژورنال: The Review of Diabetic Studies
سال: 2008
ISSN: 1613-6071,1614-0575
DOI: 10.1900/rds.2008.5.25